PIK3CA mutations in vascular malformations
نویسندگان
چکیده
منابع مشابه
Venous malformations: PIK3CA mutations guide new treatments
The Phosphoinositide 3-Kinase (PI3K) pathway has been extensively studied in tumors due its roles in promoting cellular growth and proliferation [1]. The most common PI3K mutations are in the PIK3CA gene encoding the p110α catalytic subunit, including the " hotspot " activating mutations E545K and H1047R that can lead to constitutive signaling of the pathway [1]. Consequently, activation of the...
متن کاملPIK3CA mutations in ovarian cancer.
To the Editor: In the April 15 issue of Clinical Cancer Research, Levine et al. (1) reported the frequent occurrence of somatic mutations in the phosphatidylinositol 3-kinase p110a catalytic subunit gene PIK3CA in breast and ovarian cancer. While their study broadly supports the conclusions of our previous report in these cancer types (2), there are some important differences. We observed a hig...
متن کاملvascular malformations in the maxillofacial region
congenital vascular lesions occur most often in children. parents of these children take them to maxillofacial surgeons directly or during the treatment of other complications such as infection or jaw bone disorders. various terms now used are unable to describe the pathogenesis and mechanism of the effect of vascular lesions on growth and development of facial bone. term of hemangioma is used...
متن کاملPIK3CA Mutations in Hepatocellular Carcinoma in Korea
PURPOSE Phosphatidylinositol 3-kinases/AKT pathway plays a pivotal role in hepatocellular carcinoma (HCC). Mutant PIK3CA, encoding the p110a catalytic subunit, stimulates the AKT pathway and promotes cell growth in various cancers. PIK3CA mutation rate has been usually reported as low frequency (<5%) in HCC except one report from Korea with 35.6%. Therefore, we investigated the frequency of PIK...
متن کاملVascular malformations
1. Venous malformations: congenital venous anomalies pathologically characterised by anomalous veins (thickened and hyalinised walls) separated by normal brain. These anatomically abnormal veins drain normal brain tissue. It is thought that they result from intrauterine ischemic event occurring during the formation of medullary veins resulting in collateral venous drainage. This is the most com...
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ژورنال
عنوان ژورنال: Current Opinion in Hematology
سال: 2019
ISSN: 1065-6251
DOI: 10.1097/moh.0000000000000496